{"id":5327,"date":"2023-09-18T17:10:53","date_gmt":"2023-09-18T22:10:53","guid":{"rendered":"https:\/\/www.cooking2thrive.com\/blog\/?p=5327"},"modified":"2023-09-18T17:10:53","modified_gmt":"2023-09-18T22:10:53","slug":"progress-in-reverse","status":"publish","type":"post","link":"https:\/\/www.cooking2thrive.com\/blog\/progress-in-reverse\/","title":{"rendered":"Progress in Reverse"},"content":{"rendered":"\n

Reverse vaccines are also called inverse or tolerogenic\nvaccines because, if successful, they will help your system tolerate things\nthat now trigger an adverse autoimmune response. For someone with celiac\ndisease, that could mean being able to tolerate wheat, rye, barley, and malt.\nThis would be a great relief for many people, but it won\u2019t happen tomorrow.\nResearch takes time.<\/p>\n\n\n\n

\"lab\"<\/figure><\/div>\n\n\n\n

A new Phase 1 Trial<\/a> is being held to determine whether progress in reverse will be progress forward when it comes to therapy for celiac disease. That may sound backward. And it is. Reverse in this case refers to a vaccine that will work to suppress an immune response rather than rev it up.<\/p>\n\n\n\n

The tolerogenic concept has been pursued for at least 15 years. Current treatments for the 80 known autoimmune diseases <\/a>that affect more than 5% of the population involve blocking the immune system with drugs. This is problematic because the drugs often lack specificity and leave patients at risk for side effects, opportunistic infections, and malignancies. Another downside is that the drugs must be taken for the rest of your life and they are not preventative or curative.<\/p>\n\n\n\n

In the hope of finding better options, tolerogenic mRNA\nvaccines for multiple sclerosis and rheumatoid arthritis have been explored in\ntrials using mouse models. There has been progress and the approach has\nexperienced limitations. The search for the best approach continues.<\/p>\n\n\n\n

This new celiac disease trial attempts to move the needle forward by bringing another model into play. It pulls from previous work<\/a> by Hubbell and colleagues\u2019 research that included synthetically glycosylated antigens used in an attempt to prevent Type 1 diabetes (I\u2019m greatly simplifying here). In that research, they worked from an idea that had been previously written about \u2013 using the liver\u2019s tolerogenic environment as a school in which resident antigen-presenting cells train circuiting immune cells to tolerate specific antigens and create TReg memory<\/a>. <\/p>\n\n\n\n

They explain how this works as: \u201cThe liver naturally marks\nmolecules from broken-down cells with \u2018do not attack\u2019 flags to prevent\nautoimmune reaction to cells that die by natural processes. [The glycosylation]\ncoupled an antigen with a molecule resembling a fragment of an aged cell that\nthe liver would recognize as friend, rather than foe.\u201d In an MS model, they\nwere able to demonstrate this works as an effective treatment – glycosylated\nmyelin proteins stopped neural damage and reversed symptoms. This is the\napproach they\u2019ll use in the celiac Phase 1 trial.<\/p>\n\n\n\n

The trial is small \u2013 just 41 patients. But that\u2019s common\nthese days. I\u2019ve reviewed grants for multiple studies that proposed a small\nnumber of participants. Many of those received funding. Some of them go on to\nbecome therapies. Many do not.<\/p>\n\n\n\n

It\u2019s too early to tell whether this research will result in\na successful inverse or reverse vaccine, but all research moves us forward.\nThere is much knowledge to be gained, even from studies that fail.<\/p>\n\n\n\n

If you\u2019re interested in participating in clinical trials, you can use tools like ResearchMatch<\/a> to find an appropriate match or ask your doctor or pharmacist. Not all trials involve drug research. Some focus on MRIs or a specific type of diet or workout. Others look at interventions like watching videos. Some studies pay. Others do not. <\/p>\n\n\n\n

Progress in reverse can be progress forward and we can all participate in efforts to increase knowledge. <\/p>\n","protected":false},"excerpt":{"rendered":"

Reverse vaccines are also called inverse or tolerogenic vaccines because, if successful, they will help your system tolerate things that now trigger an adverse autoimmune response. For someone with celiac disease, that could mean being able to tolerate wheat, rye, barley, and malt. This would be a great relief for many people, but it won\u2019t … Continue reading “Progress in Reverse”<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2037,116,2922,3478,3479],"_links":{"self":[{"href":"https:\/\/www.cooking2thrive.com\/blog\/wp-json\/wp\/v2\/posts\/5327"}],"collection":[{"href":"https:\/\/www.cooking2thrive.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cooking2thrive.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cooking2thrive.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cooking2thrive.com\/blog\/wp-json\/wp\/v2\/comments?post=5327"}],"version-history":[{"count":5,"href":"https:\/\/www.cooking2thrive.com\/blog\/wp-json\/wp\/v2\/posts\/5327\/revisions"}],"predecessor-version":[{"id":5333,"href":"https:\/\/www.cooking2thrive.com\/blog\/wp-json\/wp\/v2\/posts\/5327\/revisions\/5333"}],"wp:attachment":[{"href":"https:\/\/www.cooking2thrive.com\/blog\/wp-json\/wp\/v2\/media?parent=5327"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cooking2thrive.com\/blog\/wp-json\/wp\/v2\/categories?post=5327"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cooking2thrive.com\/blog\/wp-json\/wp\/v2\/tags?post=5327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}